博尔纳病病毒p40蛋白的两个结构域是与p23蛋白相互作用所必需的。

Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein.

作者信息

Berg M, Ehrenborg C, Blomberg J, Pipkorn R, Berg A L

机构信息

Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala.

出版信息

J Gen Virol. 1998 Dec;79 ( Pt 12):2957-63. doi: 10.1099/0022-1317-79-12-2957.

DOI:10.1099/0022-1317-79-12-2957

PMID:9880009

Abstract

Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190. By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein. These proteins are known to form complexes with each other and with the polymerase protein in other viruses. In this paper, it is shown that BDV p40 and p23 can form complexes with each other in infected cells. Furthermore, the amino acids of p40 that are necessary for formation of this complex have been mapped.

摘要

博尔纳病病毒（BDV）有五个主要的开放阅读框，它们编码p40、p23、gp18、p57和p190蛋白。与其他负链RNA病毒类似，p40是一种假定的核蛋白，p23是一种假定的磷蛋白。已知这些蛋白在其他病毒中会相互形成复合物，并与聚合酶蛋白形成复合物。本文表明，BDV p40和p23在受感染细胞中可相互形成复合物。此外，已确定了形成该复合物所需的p40氨基酸。