Lepage O M, Hartmann D J, Eicher R, Uebelhart B, Tschudi P, Uebelhart D
Clinic for Farm Animals and Horses, School of Veterinary Medicine, University of Berne, Switzerland.
Vet J. 1998 Nov;156(3):169-75. doi: 10.1016/s1090-0233(98)80120-2.
Concentrations of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) have been determined in the serum of one hundred clinically healthy adult Draught or Warmblood horses. The correlation between these two markers has been evaluated and the influence of gender, age and type of horse described. No significant variations were observed between animals of different sex, but a significant inverse correlation (P < 0.0001) with age was observed for both measured parameters. After correction for age, serum levels of OC were found to be lower in Draught [adjusted least square mean (LSM) = 6.612 micrograms.L-1] than in Warmblood horses (adjusted LSM = 8.596 micrograms.L-1), whereas levels of ICTP were higher in Draughts (adjusted LSM = 8.035 micrograms.L-1) than in Warmbloods (adjusted LSM = 6.643 micrograms.L-1). A significant correlation (P < 0.0001) was observed between OC and ICTP. This correlation was stronger if the type of horse was taken into account in the statistical model. The ratio OC:ICTP was independent of gender and age. A higher OC:ICTP ratio in Warmbloods compared to the Draught horses might reflect a higher bone remodelling level of horses submitted to regular daily work. It was concluded that ICTP and OC are influenced by the type of horse, and probably reflect a physiological difference in bone remodelling between these animals.
已测定了100匹临床健康的成年挽马或温血马血清中I型胶原交联羧基末端肽（ICTP）和骨钙素（OC）的浓度。评估了这两种标志物之间的相关性，并描述了性别、年龄和马匹类型的影响。不同性别的动物之间未观察到显著差异，但两个测量参数均与年龄呈显著负相关（P < 0.0001）。校正年龄后，发现挽马的血清OC水平低于温血马[校正最小二乘均值（LSM）= 6.612微克·升-1]，而挽马的ICTP水平高于温血马（校正LSM = 8.035微克·升-1）（校正LSM = 6.643微克·升-1）。OC与ICTP之间存在显著相关性（P < 0.0001）。如果在统计模型中考虑马匹类型，这种相关性更强。OC:ICTP比值与性别和年龄无关。与挽马相比，温血马的OC:ICTP比值更高，这可能反映了日常接受规律工作的马匹具有更高的骨重塑水平。得出的结论是，ICTP和OC受马匹类型的影响，可能反映了这些动物在骨重塑方面的生理差异。
