细胞凋亡中神经酰胺信号传导的多样性与复杂性

Diversity and complexity of ceramide signalling in apoptosis.

作者信息

Okazaki T, Kondo T, Kitano T, Tashima M

机构信息

Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan.

出版信息

Cell Signal. 1998 Nov;10(10):685-92. doi: 10.1016/s0898-6568(98)00035-7.

DOI:10.1016/s0898-6568(98)00035-7

PMID:9884019

Abstract

Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide-induced apoptosis.

摘要

鞘脂神经酰胺已成为一种参与细胞功能（包括分化和凋亡）的脂质信使。多种应激（紫外线、辐射、热休克和缺氧）及生物因子（肿瘤坏死因子-α、干扰素-γ和Fas抗体）都需要生成神经酰胺来诱导细胞凋亡。本文综述了神经酰胺信号在细胞凋亡中上下游关系的多样性和复杂性，以及神经酰胺诱导细胞凋亡的临床意义。