Czechowicz-Janicka K, Kamińska E, Staszkiewicz J, Terelak-Borys B, Oledzka K, Danysz A
Kliniki Okulistyki Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Klin Oczna. 1998;100(5):259-61.
It is assumed that S-timolol can produce more severe systemic adverse reactions than R-timolol. The aim of this study was to estimate the intraocular pressure-lowering effect of RS-timolol in comparison to R-timolol and S-timolol in water-loaded rabbits.
Ocular hypertension was provoked in rabbits by orogastric water loading. Topical administration of one of three timolol solutions: 0.85%, RS-timolol, or 3% R-timolol, or 0.5% S-timolol was performed to the right eyes 40 min before starting the water loading procedure. Left eyes served as a control group. Intraocular pressure was measured before and 30, 60, 90, 120 min after the water loading.
Intraocular pressure-lowering effect of all three timolol solutions was comparable.
RS-timolol can be effective for lowering intraocular pressure in rabbits.
假定S-噻吗洛尔比R-噻吗洛尔能产生更严重的全身不良反应。本研究的目的是评估在水负荷家兔中，消旋噻吗洛尔与R-噻吗洛尔和S-噻吗洛尔相比降低眼压的效果。
通过经口胃内水负荷诱导家兔高眼压。在开始水负荷程序前40分钟，对右眼局部给予三种噻吗洛尔溶液之一：0.85%消旋噻吗洛尔、3% R-噻吗洛尔或0.5% S-噻吗洛尔。左眼作为对照组。在水负荷前以及水负荷后30、60、90、120分钟测量眼压。
三种噻吗洛尔溶液降低眼压的效果相当。
消旋噻吗洛尔对降低家兔眼压有效。
Zotero 插件