Markov M, Ivanov C, Uzunov P, Ovcharov R
Sci. Institute of Pharmacology and Pharmacy, Medical Academy, Sofia, Bulgaria.
Methods Find Exp Clin Pharmacol. 1988 Jul;10(7):449-52.
The influence of compound IS-35 on intraocular pressure of unanesthetized rabbits was studied. In some cases intraocular pressure was measured with either the tonometer of Schiotz and was calculated in mmHg according to Leydhecker's scale (1973), or with the tonometer of Maclakov. Intraocular pressure was measured before and at 30, 60, 120, 180, 240 and 360 min after topical application of IS-35, timolol and trimetoquinol. It was established that IS-35 applied locally in the eye as 0.5% solution or collyrium decreases statistically significantly intraocular pressure. This effect was similar to that of timolol and exceeded significantly the effect of trimetoquinol. The experimental study on the beta-adrenergic adenylate cyclase showed that the mechanism of action of IS-35 on ophthalmotonus most probably is similar to the effect of timolol and is due to the suppression of aqueous humor formation.
研究了复方IS - 35对未麻醉家兔眼压的影响。在某些情况下，眼压用Schiotz眼压计测量，并根据Leydhecker量表（1973年）以毫米汞柱计算，或用Maclakov眼压计测量。在局部应用IS - 35、噻吗洛尔和曲美托喹后，于0、30、60、120、180、240和360分钟测量眼压。结果表明，以0.5%溶液或洗眼液局部应用于眼部的IS - 35可使眼压显著降低。这种作用与噻吗洛尔相似，且明显超过曲美托喹的作用。对β - 肾上腺素能腺苷酸环化酶的实验研究表明，IS - 35对眼压的作用机制很可能与噻吗洛尔相似，是由于抑制房水生成所致。
