血色素沉着症基因产物HFE与转铁蛋白受体的相互作用调节细胞铁代谢。

Interaction of the hemochromatosis gene product HFE with transferrin receptor modulates cellular iron metabolism.

作者信息

Eisenstein R S

机构信息

Department of Nutritional Sciences, University of Wisconsin-Madison 53706, USA.

出版信息

Nutr Rev. 1998 Dec;56(12):356-8. doi: 10.1111/j.1753-4887.1998.tb01679.x.

DOI:10.1111/j.1753-4887.1998.tb01679.x

PMID:9884584

Abstract

Mutations of a novel MHC class I-like protein, termed HFE, have been found in the vast majority of patients with the iron overload disease heredity hemochromatosis. Identification of HFE is likely to shed light on one of the major enigmas of mammalian iron homeostasis: How is intestinal iron absorption regulated?

摘要

在绝大多数患有铁过载疾病遗传性血色素沉着症的患者中，发现了一种名为HFE的新型MHC I类样蛋白的突变。HFE的鉴定可能会揭示哺乳动物铁稳态的一个主要谜团：肠道铁吸收是如何调节的？