Eisenstein R S
Department of Nutritional Sciences, University of Wisconsin-Madison 53706, USA.
Nutr Rev. 1998 Dec;56(12):356-8. doi: 10.1111/j.1753-4887.1998.tb01679.x.
Mutations of a novel MHC class I-like protein, termed HFE, have been found in the vast majority of patients with the iron overload disease heredity hemochromatosis. Identification of HFE is likely to shed light on one of the major enigmas of mammalian iron homeostasis: How is intestinal iron absorption regulated?
在绝大多数患有铁过载疾病遗传性血色素沉着症的患者中，发现了一种名为HFE的新型MHC I类样蛋白的突变。HFE的鉴定可能会揭示哺乳动物铁稳态的一个主要谜团：肠道铁吸收是如何调节的？
