Ferreira M B, Carlos A G
Immunoallergology Unit, Hospital Santa Maria, Lisbon, Portugal.
Allerg Immunol (Paris). 1998 Nov;30(9):295-7.
Even simple and relatively safe provocation procedures like nasal allergen challenges, should aim to allow detection of positivity with the less possible discomfort to the patient. The objective of this work was to evaluate if the use of rhinomanometric measurements during nasal provocation procedures could allow a decrease in the total administered allergen dose, causing less symptoms to the patients but without increasing the number of false-negatives, comparatively to clinical scores or nasal peak-flow measurements. Our results showed that performing rhinomanometric measurements during nasal HDM challenge procedures can lead in many patients to a reduction in the total dose of allergen administered during the challenge, without loss of sensitivity or specificity. This allergen dose reduction translates in less time consumed during the provocation and less patients' discomfort.
即使是像鼻过敏原激发试验这样简单且相对安全的激发程序，也应旨在在给患者带来尽可能少不适的情况下检测出阳性反应。这项工作的目的是评估在鼻激发程序中使用鼻阻力测量是否能减少过敏原的总给药剂量，在给患者带来更少症状的同时，相较于临床评分或鼻峰流速测量，又不会增加假阴性的数量。我们的结果表明，在鼻屋尘螨激发程序中进行鼻阻力测量可使许多患者在激发过程中减少过敏原的总给药剂量，且不会损失敏感性或特异性。这种过敏原剂量的减少意味着激发过程中耗时更少，患者的不适感也更低。
