Prinssen H M, Hoekman K, Burger C W
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Gynecol Oncol. 1999 Jan;72(1):116-9. doi: 10.1006/gyno.1998.5209.
A case report of lethal distant myonecrosis with gas gangrene is presented. Cultures from blood and suppuration of our patient revealed Clostridium septicum. At obduction the patient appeared to have a necrotic metastasis of a known ovarian carcinoma in the cecum wall. Predisposing conditions for this type of infection are hematologic malignancies, colon carcinoma, neutropenia, diabetes mellitus, and disruption of the bowel mucosa. Clostridium septicum is highly associated with the presence of a malignancy, either known or occult at the time infection occurs. Occult tumors are mostly situated in the cecal area of the bowel. Clinical symptoms of the syndrome and therapeutic options are discussed.
本文报告一例伴有气性坏疽的致死性远处肌坏死病例。对该患者的血液和脓液培养显示为败血梭菌。尸检时发现患者盲肠壁有已知卵巢癌的坏死转移灶。这类感染的诱发因素包括血液系统恶性肿瘤、结肠癌、中性粒细胞减少症、糖尿病以及肠黏膜破损。败血梭菌与恶性肿瘤的存在高度相关，感染发生时可为已知或隐匿性恶性肿瘤。隐匿性肿瘤大多位于肠道的盲肠区域。文中讨论了该综合征的临床症状及治疗选择。
