Boccia M M, Kopf S R, Baratti C M
Cátedra de Farmacología-Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Junín 956-5 degrees Piso, 1113-, Argentina.
Neurobiol Learn Mem. 1999 Jan;71(1):104-12. doi: 10.1006/nlme.1998.3856.
Posttraining intraperitoneal administration of phlorizin (3.0-300.0 microg/kg), a competitive inhibitor of glucose transport from blood to brain, facilitated 48-h retention, in male Swiss mice, of a one-trial step-through inhibitory avoidance task. The dose-response curve was an inverted-U shape. Phlorizin did not increase the retention latencies of mice that had not received a foot shock during training. The effects of phlorizin (30.0 microg/kg) on retention were time dependent, and the administration of phlorizin (30.0 microg/kg) 5 or 10 min prior to the retention test did not affect the retention performance of mice given posttraining injections of saline or phlorizin (30.0 microg/kg). These findings indicate that phlorizin influenced memory storage, but not memory retrieval. Finally, the simultaneous administration of phlorizin (3. 0-300.0 microg/kg, ip) antagonized, in a dose-related manner, the memory impairment induced by insulin (8 IU/kg, ip). Taken together, the results show that phlorizin enhance retention acting as a "glucose-like substance" although the mechanism(s) of this enhancement is unknown.
训练后腹腔注射根皮苷（3.0 - 300.0微克/千克），一种从血液到大脑的葡萄糖转运竞争性抑制剂，在雄性瑞士小鼠中，促进了一次性步入式抑制性回避任务的48小时记忆保持。剂量反应曲线呈倒U形。根皮苷并未增加在训练期间未接受足部电击的小鼠的记忆保持潜伏期。根皮苷（30.0微克/千克）对记忆保持的影响具有时间依赖性，在记忆测试前5或10分钟注射根皮苷（30.0微克/千克）并不影响训练后注射生理盐水或根皮苷（30.0微克/千克）的小鼠的记忆保持表现。这些发现表明根皮苷影响记忆存储，但不影响记忆检索。最后，同时腹腔注射根皮苷（3.0 - 300.0微克/千克）以剂量相关的方式拮抗了胰岛素（8国际单位/千克，腹腔注射）诱导的记忆损伤。综上所述，结果表明根皮苷作为一种“类葡萄糖物质”增强记忆保持，尽管这种增强的机制尚不清楚。
