van der Staay F J
CNS Research, Bayer AG, Neurather Ring 1, Cologne, D-51063, Germany.
Neurobiol Learn Mem. 1999 Jan;71(1):113-25. doi: 10.1006/nlme.1998.3860.
To determine whether working memory (WM) and reference memory (RM) represent different aspects of spatial memory, albino WAG rats and the pigmented Brown Norway rats were tested in the acquisition, retention, and reversal of spatial orientation tasks in the holeboard, which allows the simultaneous assessment of WM and RM. Putative nonmnemonic factors, such as the speed of visiting the holes or the development of a search strategy (preferred sequence of visiting the baited set of holes) were also evaluated because they might influence WM and RM performance. The WM performance of Brown Norway rats was generally worse than that of the WAG rats. The reverse was true for the RM performance. Correlation analysis supported the notion that these two measures are independent. Differences in the speed of visiting the holes and in the development of a preferred sequence of visiting the baited set of holes could not explain the strain differences in WM and RM performance. Because spatial WM and RM appear to be independent measures in the holeboard, this task could be used to investigate whether different neural substrate(s) underlie these two memory components.
为了确定工作记忆（WM）和参考记忆（RM）是否代表空间记忆的不同方面，对白化WAG大鼠和有色褐家鼠进行了测试，评估它们在洞板空间定向任务中的习得、保持和反转情况，该任务可同时评估WM和RM。还评估了可能的非记忆因素，如访问洞的速度或搜索策略的发展（访问有诱饵洞组的首选顺序），因为它们可能影响WM和RM表现。褐家鼠的WM表现通常比WAG大鼠差。RM表现则相反。相关分析支持了这两种测量方法相互独立的观点。访问洞的速度以及访问有诱饵洞组的首选顺序的发展差异，无法解释WM和RM表现中的品系差异。由于在洞板任务中空间WM和RM似乎是相互独立的测量方法，该任务可用于研究这两种记忆成分是否有不同的神经基质。
