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Protective effect of histidine on MPP+-induced hydroxyl radical generation in rat striatum.

作者信息

Obata T, Inada T

机构信息

Department of Pharmacology, Oita Medical University, 1-1, Hasama-machi, Oita 879-5593,

出版信息

Brain Res. 1999 Jan 30;817(1-2):206-8. doi: 10.1016/s0006-8993(98)01225-6.

DOI:10.1016/s0006-8993(98)01225-6
PMID:9889367
Abstract

We investigated the efficacy of histidine on MPP+-induced hydroxyl radical (.OH) formation in extracellular fluid of rat striatum. Rats were anesthetized and sodium salicylate in Ringer's solution (0.5 nmol microl-1 min-1) was infused through a microdialysis probe to detect the generation of.OH as reflected by the nonenzymatic formation of 2,3-dihydroxybenzoic acid (DHBA) in the striatum. MPP+ (5 mM) clearly produced an increase in.OH formation. However, histidine (25 mM) reduced the.OH formation by the action of MPP+. These results indicate that histidine protects MPP+-induced.OH formation in rat striatum.

摘要

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