de Gandarias J M, Echevarría E, Acebes I, Abecia L C, Casis O, Casis L
Department of Physiology, School of Medicine, University of the Basque Country, PO Box 699, Bilbao, Spain.
Brain Res. 1999 Jan 30;817(1-2):236-40. doi: 10.1016/s0006-8993(98)01256-6.
Fluoxetine is a selective serotonin reuptake inhibitor. Analysis of mu-opioid receptor immunostaining after chronic fluoxetine administration in rats revealed an increase in the density of cells expressing mu-opioid receptors in the caudatus-putamen, the dentate gyrus, the lateral septum and the frontal, parietal and piriform cortices. These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.
