Duhault J, Tisserand F, Regnier G
Arzneimittelforschung. 1976 Apr;26(4):516-23.
1-Phenethyl-4-hydroxy-salicylamido-4-methylpiperidine-hydrochloride (S 1592) markedly inhibits coughing induced in laboratory animals by chemical or mechanical irritation of respiratory tract or by electrical stimulation of the superior laryngeal nerve. The drug has low acute toxicity in mice and rats. The new compound possesses bronchodilating and antianaphylactic properties and does not affect gastrointestinal propulsion. Cardiovascular effects are absent.
1-苯乙基-4-羟基-水杨酰胺基-4-甲基哌啶盐酸盐（S 1592）能显著抑制实验动物因呼吸道化学或机械刺激或喉上神经电刺激所诱发的咳嗽。该药物对小鼠和大鼠的急性毒性较低。这种新化合物具有支气管扩张和抗过敏特性，且不影响胃肠蠕动。无心血管效应。
