Schillinger E, Loge O
Arzneimittelforschung. 1976 Apr;26(4):554-6.
Chronic oral treatment of male diabetic Chinese hamsters with 100 mg/kg/day 5-methoxyindole-2-carboxylic acid (MICA) causes a depression of blood glucose in fasted animals and an improvement in the glucose profile in fed animals. Glycogen levels in the liver and body weight are decreased. Treated animals die at a higher rate than do controls. It is concluded that treatment with a potent inhibitor of gluconeogenesis like MICA will not provide a useful tool in managing diabetes.
对雄性中国糖尿病仓鼠进行慢性口服治疗，每天给予100毫克/千克的5-甲氧基吲哚-2-羧酸（MICA），会使禁食动物的血糖降低，进食动物的血糖曲线得到改善。肝脏中的糖原水平和体重下降。治疗组动物的死亡率高于对照组。得出的结论是，用像MICA这样的强力糖异生抑制剂进行治疗，在糖尿病管理中不会成为一个有用的工具。
