Lapes M, Antoniades K, Gartner W, Vivacqua R
Cancer. 1976 Sep;38(3):1318-22. doi: 10.1002/1097-0142(197609)38:3<1318::aid-cncr2820380334>3.0.co;2-0.
A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.
本文描述了一名患有经典型涎腺良性淋巴上皮病变（BLL）的患者，该病变转变为局限于涎腺的淋巴母细胞淋巴瘤（LSA）。BLL的恶性转化发生在苯妥英抗惊厥治疗之后，LSA发生后进行的体外试验显示苯妥英诱导淋巴细胞转化呈阳性。该淋巴瘤通过局部放疗、化疗以及停用苯妥英得到成功治疗。该病例说明了某些患者中BLL的“淋巴瘤前期”性质，以及文中所讨论的苯妥英和其他淋巴刺激药物可能存在的潜在危险。有必要对淋巴瘤前期疾病患者中能够诱导淋巴细胞转化的药物进行进一步研究。
