Berry J M, Kowalski A, Fletcher S A
Department of Anesthesiology, University of Texas-Houston Health Science Center, USA.
J Neurosurg Anesthesiol. 1999 Jan;11(1):42-5. doi: 10.1097/00008506-199901000-00008.
The authors report a case of intraoperative sinus arrest in an otherwise healthy patient undergoing craniotomy for aneurysm clipping after mild subarachnoid hemorrhage. The sinus arrest was precipitated by a rapid infusion of 1500 mg phenytoin and was successfully treated with standard resuscitative measures. The differential diagnosis of intraoperative cardiac arrest and the mechanisms of action of phenytoin are discussed. The authors emphasize the role of phenytoin in cerebral protection.
作者报告了一例在轻度蛛网膜下腔出血后接受开颅动脉瘤夹闭术的健康患者术中发生窦性停搏的病例。窦性停搏是由快速输注1500毫克苯妥英钠引发的，并通过标准复苏措施成功治疗。文中讨论了术中心脏骤停的鉴别诊断以及苯妥英钠的作用机制。作者强调了苯妥英钠在脑保护中的作用。
