[血浆中异烟肼的测定]
[Determination of isoniazid in blood plasma].
作者信息
Bourdon R, Pollet J, Nicaise A M
出版信息
Ann Biol Clin (Paris). 1976;34(2):127-31.
PMID:9891
Abstract
The authors describe a new method of estimation of isoniazid in biological fluids, based on the formation and extraction of aluminium chelate obtained after combination of the isoniazid with salicylic aldehyde. The study of conditions of defecation and reaction permits one to eliminate interference with the metabolites, especially the acido-labile metabolites and obtain results comparable with those of microbiological methods.
摘要
作者描述了一种在生物体液中测定异烟肼的新方法，该方法基于异烟肼与水杨醛结合后形成铝螯合物并进行萃取。对分离和反应条件的研究使得能够消除与代谢物的干扰，尤其是对酸不稳定的代谢物，并获得与微生物学方法相当的结果。
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