Thornbury J R
University of Wisconsin at Madison, USA.
Acad Radiol. 1999 Jan;6 Suppl 1:S58-65; discussion S66-8. doi: 10.1016/s1076-6332(99)80088-9.
The conceptual basis for intermediate outcomes has been established, and scientifically sound methods are available for assessment of these short-term outcomes. While modest intermediate outcomes research experience assessing imaging technology has accumulated in the literature, much more remains to be done, for the benefit of both patients and physicians. I would recommend that intermediate outcomes research become more focused on assessment earlier in the diffusion phase of imaging technology development. These studies should be based on traditional diagnostic accuracy studies, but these should be extended to include well-designed, high scientific quality treatment impact studies. Furthermore, such studies need to be multidisciplinary and multiinstitutional/multisite and include patient utility assessment components.
中间结局的概念基础已经确立，并且有科学合理的方法可用于评估这些短期结局。虽然文献中已经积累了一定的评估成像技术的中间结局研究经验，但为了患者和医生的利益，仍有许多工作要做。我建议中间结局研究应更侧重于在成像技术发展的传播阶段早期进行评估。这些研究应基于传统的诊断准确性研究，但应扩展到包括精心设计、具有高科学质量的治疗效果研究。此外，此类研究需要多学科、多机构/多地点进行，并包括患者效用评估部分。
