bcl-2与p53联合表达作为乳腺癌预后因素的相关性。
Relevance of the expression of bcl-2 in combination with p53 as a prognostic factor in breast cancer.
作者信息
Jansen R L, Joosten-Achjanie S R, Volovics A, Arends J W, Hupperets P S, Hillen H F, Schouten H C
机构信息
Department of Internal Medicine, University of Maastricht, The Netherlands.
出版信息
Anticancer Res. 1998 Nov-Dec;18(6A):4455-62.
BACKGROUND
Both the proto-oncogene bcl-2 and the tumour suppressor gene p53 are involved in the regulation of apoptosis.
PATIENTS AND METHODS
We have investigated the prognostic value of the immunohistochemical expression of p53 and bcl-2 separately and in combination in a group of 345 breast cancer patients from one hospital with a long median follow-up of more than 10 years.
RESULTS
Bcl-2 expression was not a prognostic factor. p53 was an independent prognostic factor for overall survival (p = 0.005) and for post-relapse survival (p = 0.006). Looking at bcl-2/p53 subgroups in the bcl-2 positive subgroup there was a large difference in both disease-free and overall survival between p53 negative and p53 positive patients. In the bcl-2 negative subgroup the p53 status was not a prognostic factor at all.
CONCLUSIONS
p53 is an independent prognostic factor for overall survival and post-relapse survival. However, p53 status is only important in the bcl-2 positive subgroup.
背景
原癌基因bcl-2和肿瘤抑制基因p53均参与细胞凋亡的调控。
患者与方法
我们对一家医院的345例乳腺癌患者进行了研究，分别单独及联合检测p53和bcl-2的免疫组化表达情况，这些患者的中位随访期超过10年。
结果
bcl-2表达不是一个预后因素。p53是总生存期（p = 0.005）和复发后生存期（p = 0.006）的独立预后因素。观察bcl-2阳性亚组中的bcl-2/p53亚组，p53阴性和p53阳性患者在无病生存期和总生存期方面均存在很大差异。在bcl-2阴性亚组中，p53状态根本不是一个预后因素。
结论
p53是总生存期和复发后生存期的独立预后因素。然而，p53状态仅在bcl-2阳性亚组中具有重要意义。
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