病毒内分泌转化：病毒转化蛋白与细胞信号转导通路之间的交叉点。

Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.

作者信息

DiMaio D, Lai C C, Klein O

机构信息

Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

出版信息

Annu Rev Microbiol. 1998;52:397-421. doi: 10.1146/annurev.micro.52.1.397.

DOI:10.1146/annurev.micro.52.1.397

Abstract

This review describes a mechanism of viral transformation involving activation of cellular signaling pathways. We focus on four viral oncoproteins: the E5 protein of bovine papillomavirus, which activates the platelet-derived growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen, which resembles an activated receptor tyrosine kinase; and LMP-1 of Epstein-Barr virus, which mimics an activated tumor necrosis factor receptor. These examples indicate that diverse viruses induce cell transformation by activating cellular signal transduction pathways. Study of this mechanism of viral transformation will provide new insights into viral tumorigenesis and cellular signal transduction.

摘要

本综述描述了一种涉及细胞信号通路激活的病毒转化机制。我们重点关注四种病毒癌蛋白：牛乳头瘤病毒的E5蛋白，其激活血小板衍生生长因子β受体；脾集落形成病毒的gp55，其激活促红细胞生成素受体；多瘤病毒中T抗原，其类似于活化的受体酪氨酸激酶；以及爱泼斯坦-巴尔病毒的LMP-1，其模拟活化的肿瘤坏死因子受体。这些例子表明，多种病毒通过激活细胞信号转导通路诱导细胞转化。对这种病毒转化机制的研究将为病毒致瘤和细胞信号转导提供新的见解。

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