三种本土药物在实验性诱导动脉粥样硬化中的降血脂活性。

Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis.

作者信息

Shaila H P, Udupa S L, Udupa A L

机构信息

Dept. of Biochemistry, Kasturba Medical College, Manipal, India.

出版信息

Int J Cardiol. 1998 Dec 1;67(2):119-24. doi: 10.1016/s0167-5273(98)00281-2.

DOI:10.1016/s0167-5273(98)00281-2

PMID:9891944

Abstract

The effect of orally administered indigenous drugs Terminalia arjuna, T. belerica and T. chebula were investigated on experimental atherosclerosis. Rabbits were fed a cholesterol-rich diet to induce atherosclerosis. The three drugs were fed along with cholesterol. At the end of the experimental period the animals were killed and their plasma and tissue lipid components estimated. Atherosclerotic lesions of the aorta were examined histologically. T. arjuna was found to be the most potent hypolipidemic agent and induced partial inhibition of rabbit atheroma. The results indicate that T. arjuna may play an anti-atherogenic role.

摘要

研究了口服印度本土药物诃子、毗黎勒和余甘子对实验性动脉粥样硬化的影响。给兔子喂食富含胆固醇的饮食以诱导动脉粥样硬化。将这三种药物与胆固醇一起喂食。在实验期结束时，处死动物并估计其血浆和组织脂质成分。对主动脉的动脉粥样硬化病变进行组织学检查。发现诃子是最有效的降血脂药物，并能部分抑制兔动脉粥样瘤。结果表明，诃子可能发挥抗动脉粥样硬化作用。