安娜·帕瓦拉·辛杜拉姆对实验性动脉粥样硬化中血浆和主动脉脂质的影响。

Effect of Anna Pavala Sindhooram on plasma and aortic lipids in experimental atherosclerosis.

作者信息

Marita A R, Shanmugasundaram K R

出版信息

Atherosclerosis. 1982 Dec;45(3):331-43. doi: 10.1016/0021-9150(82)90234-9.

Abstract

The effect of orally administered Anna Pavala Sindhooram (APS), a herbo-mineral Sidha formulation was investigated on experimental atherosclerosis. Rabbits were fed a cholesterol rich (0.5%) diet for 6 months to induce atherosclerosis. These animals were then divided into six groups and given 50 mg of APS powder/day/animal for a further 6 months. At the end of the experimental period the animals were killed, and their plasma and aortic lipid components estimated. Atherosclerotic lesions of the aorta were quantified and examined histologically. Synthesis of lipids using [14C]acetate as a precursor was studied after i.v. injection. APS was found to be hypolipidemic and induced partial regression of rabbit atheroma and decreased lipogenesis. The results indicate that APS may play an anti-atherogenic role if used in larger doses.

摘要

研究了口服草药-矿物悉达配方Anna Pavala Sindhooram（APS）对实验性动脉粥样硬化的影响。给兔子喂食富含胆固醇（0.5%）的饮食6个月以诱导动脉粥样硬化。然后将这些动物分为六组，连续6个月每天给每只动物50毫克APS粉末。实验期结束时处死动物，估计其血浆和主动脉脂质成分。对主动脉的动脉粥样硬化病变进行定量并进行组织学检查。静脉注射后，以[14C]乙酸盐为前体研究脂质合成。发现APS具有降血脂作用，可诱导兔动脉粥样瘤部分消退并减少脂肪生成。结果表明，如果使用更大剂量，APS可能发挥抗动脉粥样硬化作用。