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部分左心室切除术:围手术期死亡率的术前危险因素。

Partial left ventriculectomy: preoperative risk factors for perioperative mortality.

作者信息

Bestetti R B, Moreira-Neto F, Brasil J C, Bombonato R, Sgarbieri R N, Haddad J

机构信息

UNAERP Medical School, São Francisco Hospital, Ribeirão Preto, Brazil.

出版信息

Int J Cardiol. 1998 Dec 1;67(2):143-6.

PMID:9891947
Abstract

This study aimed at determining risk factors for perioperative mortality for patients undergoing partial left ventriculectomy. Fourteen patients with end-stage congestive heart failure underwent partial ventriculectomy at our institution from February, 1995 to October, 1997. Mean age was 48+/-11 years, symptoms duration 44+/-34 months, New York Heart Association symptoms score 4+/-0, systolic blood pressure 97.69+/-20.06 mmHg, diastolic blood pressure 65.38+/-13.91 mmHg, heart rate 91+/-15 beats/min, furosemide daily dose 121.66+/-96.65 mg and captopril daily dose 68.75+/-76.76 mg. Seven (50%) patients needed inotropic support for hemodynamic stabilization. On echocardiography, left ventricular diastolic dimension was 81.71+/-11.92 mm. Left ventricular ejection fraction determined by radionuclide ventriculography or echocardiography was 16.71+/-5.13. At heart catheterization, mean right atrial pressure was 12.50+/-7.72 mmHg, mean pulmonary capillary wedge pressure 23.60+/-7.79 mmHg, and mean pulmonary artery pressure 34.10+/-12.81 mmHg. Twelve patients had idiopathic dilated cardiomyopathy and two patients had a globally dilated heart with single vessel coronary artery disease. Aneurysmectomy, mitral valve surgery or coronary artery bypass surgery were not performed in any patient. Four (28%) patients died: three in the operating theatre and one from low output syndrome 2 days after surgery. The proportion of patients operated on with cardiogenic shock was four (100%) in nonsurvivors and 0% in survivors (P=0.001). Inotropic support was necessary in three (30%) survivors and in four (100%) nonsurvivors (P=0.06). Thus, preoperative hemodynamic instability may be associated with perioperative mortality after partial left ventriculectomy.

摘要

本研究旨在确定接受部分左心室切除术患者围手术期死亡的危险因素。1995年2月至1997年10月,14例终末期充血性心力衰竭患者在我院接受了部分心室切除术。平均年龄为48±11岁,症状持续时间为44±34个月,纽约心脏协会症状评分4±0,收缩压97.69±20.06 mmHg,舒张压65.38±13.91 mmHg,心率91±15次/分钟,呋塞米每日剂量121.66±96.65 mg,卡托普利每日剂量68.75±76.76 mg。7例(50%)患者需要使用血管活性药物支持以稳定血流动力学。超声心动图显示,左心室舒张内径为81.71±11.92 mm。通过放射性核素心室造影或超声心动图测定的左心室射血分数为16.71±5.13。心导管检查时,平均右心房压力为12.50±7.72 mmHg,平均肺毛细血管楔压为23.60±7.79 mmHg,平均肺动脉压力为34.10±12.81 mmHg。12例患者患有特发性扩张型心肌病,2例患者患有全心扩大并单支冠状动脉疾病。所有患者均未进行动脉瘤切除术、二尖瓣手术或冠状动脉搭桥手术。4例(28%)患者死亡:3例死于手术室,1例术后2天死于低心排血量综合征。非幸存者中接受手术时伴有心源性休克的患者比例为4例(100%),幸存者中为0%(P = 0.001)。3例(30%)幸存者和4例(100%)非幸存者需要血管活性药物支持(P = 0.06)。因此,术前血流动力学不稳定可能与部分左心室切除术后的围手术期死亡有关。

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