Robyn C, Vekemans M
Acta Endocrinol (Copenh). 1976 Sep;83(1):9-14. doi: 10.1530/acta.0.0830009.
The effect on serum prolactin, LH and FSH levels of 25 mug ethinyloestradiol administered daily per os during 27 consecutive days was investigated in 5 post-menopausal women aged 52-78. Blood samples were collected before, during and after treatment. The hormones were assayed in serum by radioimmunological methods. Both LH and FSH decreased progressively and significantly from 120 and 115 mIU/ml before treatment to 52 and 51 mIU/ml, respectively after three weeks of oestrogen administration. Two weeks after interruption of treatment, LH (90mIU/ml) and FSH (112 mIU/ml) were significantly higher than during the last week of treatment. Mean prolactin level increased from 127 muU/ml before treatment to 237 muU/ml after 10 days of oestrogen administration (P less than 0.001). This increase was significant after 4 to 8 days and the levels remained about twice as high as the control values for the rest of the treatment period. Two weeks after interruption of treatment, serum prolactin had fallen (136 muU/ml) to the pre-treatment levels. Such results raise the question of possible effects of elevated levels of this hormone during long term oestrogen medication in post-menopausal women on the development of breast cancer.
对5名年龄在52 - 78岁的绝经后女性连续27天每日口服25微克乙炔雌二醇后血清催乳素、促黄体生成素（LH）和促卵泡生成素（FSH）水平的影响进行了研究。在治疗前、治疗期间和治疗后采集血样。采用放射免疫法测定血清中的激素。雌激素给药三周后，LH和FSH分别从治疗前的120和115 mIU/ml逐渐显著下降至52和51 mIU/ml。治疗中断两周后，LH（90 mIU/ml）和FSH（112 mIU/ml）显著高于治疗最后一周的水平。平均催乳素水平从治疗前的127 μU/ml在雌激素给药10天后升至237 μU/ml（P < 0.001）。4至8天后这种升高显著，并且在治疗期的其余时间里水平保持在对照值的两倍左右。治疗中断两周后，血清催乳素已降至（136 μU/ml）治疗前水平。这些结果提出了绝经后女性长期雌激素用药期间该激素水平升高对乳腺癌发生可能产生影响的问题。
