Lin K H, You S L, Chen C J, Wang C F, Yang C S, Yamazaki S
Department of Clinical Laboratory, Kaohsiung Medical College, Taiwan, Republic of China.
J Med Virol. 1999 Feb;57(2):169-73.
In order to determine the prevalence and risk factors of human parvovirus B19 (B19) infection in Taiwan, a seroepidemiological study was carried out in 19 townships. Serum samples were collected from 862 healthy residents, who were selected by stratified random sampling from various study areas. They were chosen from four different ethnic groups including aborigines, Fukien Taiwanese, Hakka Taiwanese, and mainland Chinese. Serum samples were screened for B19 IgG antibody by indirect antibody capture enzyme-linked immunosorbent assay (ELISA) and B19 IgM by IgM antibody capture (MAC)-ELISA, respectively. The overall prevalence of anti-B19 IgG and anti-B19 IgM was 32.8% and 0.35%, respectively. The anti-B19 seropositive rate in females was significantly higher than that of males (36.4% vs. 29.4%, P < .001). The age-sex-adjusted seropositive rate in urban townships (39.9%) was higher than that in aboriginal townships (30.5%, P < .001). The seropositive rate increased significantly with age showing a dose-response relationship (P=0.0001 based on a trend test). Blood transfusion was found to be associated with an increased seropositive rate showing a multivariate-adjusted odds ratios of 1.6.
为了确定台湾地区人类细小病毒B19（B19）感染的流行率及危险因素，在19个乡镇开展了一项血清流行病学研究。从862名健康居民中采集血清样本，这些居民是从各个研究区域通过分层随机抽样选取的。他们来自四个不同的族群，包括原住民、台湾闽南人、台湾客家人和中国大陆人。分别采用间接抗体捕获酶联免疫吸附测定（ELISA）检测血清样本中的B19 IgG抗体，采用IgM抗体捕获（MAC）-ELISA检测B19 IgM。抗B19 IgG和抗B19 IgM的总体流行率分别为32.8%和0.35%。女性的抗B19血清阳性率显著高于男性（36.4%对29.4%，P <.001）。城市乡镇经年龄-性别调整后的血清阳性率（39.9%）高于原住民乡镇（30.5%，P <.001）。血清阳性率随年龄显著增加，呈现剂量反应关系（基于趋势检验，P = 0.0001）。发现输血与血清阳性率增加相关，多变量调整后的优势比为1.6。
