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直立性低血压时心肌肾上腺素能神经功能异常。

Abnormal myocardial adrenergic nerve function in orthostatic hypotension.

作者信息

Nakamura M, Yamazaki T, Hiramori K

机构信息

Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan.

出版信息

Cardiology. 1998 Dec;90(3):236-8. doi: 10.1159/000006850.

DOI:10.1159/000006850
PMID:9892775
Abstract

A 70-year-old man had frequent syncope and faintness when in an upright position. A diagnosis of primary orthostatic hypotension was obtained by a head-up tilt test and various autonomic nerve function tests. No abnormalities were seen on myocardium scintigraphy using 201Tl. However, 123I-metaiodobenzyl-guanidine did not accumulate in the heart. This suggests that globally denervated myocardium may impair a prompt increase in cardiac contractility and fail to maintain cerebral blood flow, thereby contributing to postural hypotension in this disorder.

摘要

一名70岁男性在直立位时频繁出现晕厥和头晕。通过头高位倾斜试验及各种自主神经功能测试确诊为原发性直立性低血压。使用201Tl进行的心肌闪烁扫描未见异常。然而,123I-间碘苄胍未在心脏中积聚。这表明整体去神经支配的心肌可能会损害心脏收缩力的迅速增加,并无法维持脑血流量,从而导致该疾病中的体位性低血压。

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