疾病肾脏中内皮素的作用靶点：治疗干预线索

Targets for endothelin in the diseased kidney: clues for therapeutic intervention.

作者信息

Rohmeiss P, Birck R, Braun C, Kirchengast M, van der Woude F J

机构信息

Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Germany.

出版信息

Exp Nephrol. 1999 Jan-Feb;7(1):1-10. doi: 10.1159/000020577.

DOI:10.1159/000020577

PMID:9892807

Abstract

The endothelin system has been implicated in various renal diseases. This review focuses on the involvement of endothelin-1 in pathogenesis and pathophysiology of acute and chronic renal failure with regard to its hemodynamic and nonhemodynamic effects. Future developments concerning the use of endothelin receptor antagonists and the role of endothelin in the kidney transplantation setting are discussed.

摘要

内皮素系统已被认为与多种肾脏疾病有关。本综述重点关注内皮素-1在急性和慢性肾衰竭的发病机制及病理生理学中的作用，涉及到其血流动力学和非血流动力学效应。同时还讨论了内皮素受体拮抗剂应用的未来发展以及内皮素在肾移植中的作用。