Fünistück R, Stein G, Krohs G, Sperschneider H, Stelzner A, Süsse I, Waldmann G
Z Urol Nephrol. 1978 Jun;71(6):375-83.
In 53 patients (19 women, 34 men), of them 41 patients with an intracapillary proliferative glomerulonephritis, 9 with membranous proliferative and 3 with a membranous glomerulonephritis under an indometacin therapy examinations concerning proteinuria were carried out, partly with determination of the index of selectivity and representation of the protein clearance. In patients with a moderate proteinuria of less than 3 g a day this treatment achieved a smaller antiproteinurie effect than in patients with a large proteinuria. When a large activity of the inflammatory process was present a therapeutic success was less frequently to be proved. An unequivocal correlation between the histological course of the disease and the change of the proteinuria could not be recognized. After cautious estimation of the findings the selectivity of the proteinuria may be regarded as a certain indicator for the application of indometacin. The protein clearance, however, proved less suitable for the judgment of the treatment performed.
在53例患者（19名女性，34名男性）中，41例患有毛细血管内增生性肾小球肾炎，9例患有膜增生性肾小球肾炎，3例患有膜性肾小球肾炎，对这些患者进行了吲哚美辛治疗下有关蛋白尿的检查，部分检查包括选择性指数的测定和蛋白质清除率的测定。与蛋白尿量大的患者相比，该治疗对每日蛋白尿少于3g的中度蛋白尿患者的抗蛋白尿作用较小。当存在炎症过程的高活性时，治疗成功的情况较少得到证实。无法识别疾病的组织学进程与蛋白尿变化之间的明确相关性。在谨慎评估研究结果后，蛋白尿的选择性可被视为应用吲哚美辛的某种指标。然而，蛋白质清除率被证明不太适合判断所进行的治疗。
