Jahangir M, Hussain I, Ul Hasan M, Haroon T S
Department of Dermatology, King Edward Medical College/Mayo Hospital, Lahore,
Br J Dermatol. 1998 Oct;139(4):672-4. doi: 10.1046/j.1365-2133.1998.02465.x.
In this randomized, double-blind study, the efficacy and safety of oral itraconazole (n = 28) and terbinafine (n = 27), each given for 2 weeks, was compared in patients with tinea capitis. Trichophyton violaceum was the major pathogen in both groups (82.1% and 88.9%, respectively). The final evaluation at week 12 showed a cure rate of 85.7% and 77.8%, respectively (P > 0.05). Adverse events noted were mild and did not warrant discontinuation of therapy.
在这项随机、双盲研究中,对28例头癣患者口服伊曲康唑(疗程2周)和27例头癣患者口服特比萘芬(疗程2周)的疗效和安全性进行了比较。紫色毛癣菌是两组中的主要病原体(分别为82.1%和88.9%)。第12周的最终评估显示治愈率分别为85.7%和77.8%(P>0.05)。观察到的不良事件均较轻微,无需停止治疗。