Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S
Department of Dermatology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Br J Dermatol. 1998 Nov;139(5):897-901. doi: 10.1046/j.1365-2133.1998.02522.x.
We report a case of Hailey-Hailey disease (HHD) in which 1alpha, 24-dihydroxyvitamin D3 (tacalcitol) was effective both clinically (in vivo) and in explant cultures (in vitro) of a skin lesion. The patient was a 65-year-old man with HHD lesions in the axillary and inguinal areas bilaterally. We applied ointment containing 1alpha, 24-dihydroxyvitamin D3 (tacalcitol), an analogue of active vitamin D3, to the lesions and assessed its clinical effectiveness. The HHD lesions in both groins disappeared after treatment with the 1alpha, 24-dihydroxyvitamin D3 ointment, and the remission has continued to the present. A punch biopsy specimen of the lesion that had remitted showed no acantholysis. In addition, dissociation of migrating keratinocytes was observed when biopsy specimens of the HHD skin lesion were cultured in medium without 1alpha,24-dihydroxyvitamin D3, but inhibition of keratinocyte dissociation was observed in medium containing it. These results suggest the effectiveness of 1alpha, 24-dihydroxyvitamin D3 against HHD both in vivo and in vitro.
我们报告了一例海利-海利病（HHD），其中1α,24-二羟基维生素D3（他卡西醇）在临床（体内）和皮肤病变的外植体培养（体外）中均有效。患者为一名65岁男性，双侧腋窝和腹股沟区患有HHD病变。我们将含有活性维生素D3类似物1α,24-二羟基维生素D3（他卡西醇）的软膏应用于病变部位，并评估其临床疗效。使用1α,24-二羟基维生素D3软膏治疗后，双侧腹股沟的HHD病变消失，且缓解持续至今。已缓解病变的打孔活检标本未显示棘层松解。此外，当将HHD皮肤病变的活检标本在不含1α,24-二羟基维生素D3的培养基中培养时，观察到迁移角质形成细胞的解离，但在含有它的培养基中观察到角质形成细胞解离受到抑制。这些结果表明1α,24-二羟基维生素D3在体内和体外对HHD均有效。
