Pollock B, Bock P R, Fuchs A M, Lohaus R
Arzneimittelforschung. 1976;26(3):327-34.
By means of a modified and simplified surgical and implantation technique, standardized values for visually evoked potentials (EP) from 7 brain structures (caudate nucleus, posterior hypothalamus, mesencephalic reticular formation, intra-laminar thalamic nuclei, amygdala, dorsal hippocampus and visual cortex) are obtained. The importance of a careful selection of the animal material, constant test conditions and the selection of test parameters as a prerequisite for the assessment of psychotropic drugs is emphasized and discussed. As an example of the specific influence on visually evoked potentials in the above named brain structures, the effects of haloperidol and amytriptyline on latencies and amplitudes of the individual parameters of EPs are described. It is assumed that the method described can be of great assistance for investigation and classification of newly developed substances.
通过一种改良和简化的手术及植入技术，获得了来自7个脑结构（尾状核、下丘脑后部、中脑网状结构、丘脑板内核、杏仁核、背侧海马体和视觉皮层）的视觉诱发电位（EP）的标准化值。强调并讨论了仔细选择动物材料、恒定的测试条件以及选择测试参数作为评估精神药物前提条件的重要性。作为对上述脑结构中视觉诱发电位的具体影响的一个例子，描述了氟哌啶醇和阿米替林对EP各个参数的潜伏期和振幅的影响。假定所描述的方法对新开发物质的研究和分类有很大帮助。
