Kasé Y, Kito G, Miyata T, Takahama K, Uno T
Arzneimittelforschung. 1976;26(3):361-6.
The sites of antitussive action of d-3-methyl-N-methylmorphinan (AT-17) were studied. It was assumed from the following results that AT-17 acts on the cough centre per se. a) When AT-17 was given by the routes leading to the brain stem such as the cerebello-medullar cistern, far smaller doses were sufficient to obtain the same effect as that by i.v. administration. b) It showed neither effect on the afferent pathway for cough reflex nor influence on pulmonary stretch receptors. c) Decerebration exerted no influence on the antitussive efficacy. d) It definitely depressed the potentials of both the recurrent and internal intercostal nerves evoked by the superior laryngeal nerve stimulation. e) Micro-injection of AT-17 into the bilateral solitary nuclei or their adjacent regions inhibited coughs induced by peripheral stimulation. f) In deafferentated and decerebrate cats, AT-17 increased the spontaneous discharges of the phrenic nerve, whereas codeine decreased them.
研究了d-3-甲基-N-甲基吗啡喃（AT-17）的镇咳作用部位。从以下结果推测，AT-17本身作用于咳嗽中枢。a）当通过诸如小脑延髓池等通向脑干的途径给予AT-17时，所需剂量远小于静脉给药获得相同效果所需的剂量。b）它对咳嗽反射的传入途径既无作用，对肺牵张感受器也无影响。c）去大脑对镇咳效果无影响。d）它能明确抑制由喉上神经刺激诱发的肋间神经和肋间内神经的电位。e）向双侧孤束核或其相邻区域微量注射AT-17可抑制外周刺激诱发的咳嗽。f）在去传入神经和去大脑的猫中，AT-17增加膈神经的自发放电，而可待因则使其减少。
