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硝酸镨致大鼠急性肝损伤(作者译)

[Acute liver injury in rats by praseodymium nitrate (author's transl)].

作者信息

Schriewer H, Gebauer B, Rauen H M

出版信息

Arzneimittelforschung. 1976;26(3):399-402.

PMID:989335
Abstract

After acute intoxication with praseodymium nitrate (10 mg/kg body weight i.v.), time functions of enzyme activities of GOT, GPT, ChE, AP and of free fatty acids concentration in rat serum were analysed and the results subjected to significance and correlation analysis. Time functions of free fatty acids concentration corresponded with those of enzyme activities of GOT and GPT. In the early state of intoxication serum concentrations of palmitoleinic and oleic acid were more increased than those of stearinic acid. There seems to be an alteration in the correlations of analysed measures with regard to their temporal changes parallel to the progress of intoxication.

摘要

给大鼠静脉注射硝酸镨(10毫克/千克体重)致急性中毒后,分析了大鼠血清中谷草转氨酶(GOT)、谷丙转氨酶(GPT)、胆碱酯酶(ChE)、碱性磷酸酶(AP)的酶活性以及游离脂肪酸浓度随时间的变化情况,并对结果进行了显著性和相关性分析。游离脂肪酸浓度随时间的变化情况与GOT和GPT的酶活性随时间的变化情况相对应。在中毒早期,血清中棕榈油酸和油酸的浓度升高幅度大于硬脂酸。随着中毒进程的推进,所分析指标的相关性似乎在其时间变化方面发生了改变。

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