Dinelli C A, Gironi A, Lomazzi A, Montrasio P L, Ratti L
Arzneimittelforschung. 1976;26(3):421-4.
The effect of N-ethyl-2(2-methoxy-5-sulfamido-benzamidomethyl-pyrrolidine (sulpiride, Dobren) on serum gastrin in patients with duodenal ulcer was evaluated. A statistically significant decrease in gastrinemia was observed. The possible mode of action of sulpiride is discussed. It is suggested that sulpiride by acting on the hypothalamus could possibly normalize the alterations of the mucosal barrier and restore the feed-back mechanism implicated in the autoregulation of antral gastrin secretion.
评估了N-乙基-2（2-甲氧基-5-磺酰胺基-苯甲酰胺基甲基）吡咯烷（舒必利，多必能）对十二指肠溃疡患者血清胃泌素的影响。观察到胃泌素血症有统计学意义的下降。讨论了舒必利可能的作用方式。有人提出，舒必利通过作用于下丘脑可能使黏膜屏障的改变正常化，并恢复与胃窦胃泌素分泌自动调节有关的反馈机制。
