儿童和青少年体内去甲丙咪嗪的清除率：发育和性别的影响缺失

Desipramine clearance in children and adolescents: absence of effect of development and gender.

作者信息

Cohen L G, Biederman J, Wilens T E, Spencer T J, Mick E, Faraone S V, Prince J, Flood J G

机构信息

Department of Pharmacy, Massachusetts General Hospital, Boston 02114, USA.

出版信息

J Am Acad Child Adolesc Psychiatry. 1999 Jan;38(1):79-85. doi: 10.1097/00004583-199901000-00023.

DOI:10.1097/00004583-199901000-00023

PMID:9893420

Abstract

OBJECTIVE

To examine the influence of development and gender on the pharmacokinetics of desipramine (DMI) in the pediatric population.

METHOD

DMI pharmacokinetic parameters were calculated from 407 routinely drawn, dose- and weight-normalized serum concentrations in 173 youths receiving DMI (90 children, 83 adolescents; 29 were female, 144 were male).

RESULTS

Mean pharmacokinetic parameters for the entire population included dose (3.78 +/- 1.51 mg/kg), weight- and dose-normalized serum concentration (45.41 +/- 47.39 [micrograms/L]/[mg/kg]), and DMI clearance (0.68 +/- 1.51 [L/kg]/hr). No between-group differences for children and adolescents were detected in dose (child, adolescent) (3.73 +/- 1.40 mg/kg, 3.83 +/- 1.68 mg/kg), weight- and dose-normalized serum concentrations (44.52 +/- 39.6 [micrograms/L]/[mg/kg], 46.34 +/- 34.89 [micrograms/L]/[mg/kg]; p = .62), and clearance (0.680 +/- 0.890 [L/kg]/hr, 0.695 +/- 1.05 [L/kg]/hr; p = .103). No between-group gender differences were detected in dose (male, female) (3.83 +/- 1.55 mg, 3.39 +/- 1.84 mg), weight- and dose-normalized serum concentrations (45.15 +/- 37.76 [micrograms/L]/[mg/kg], 47.14 +/- 34.96 [micrograms/L]/mg/kg]; p = .720), and clearance (0.699 +/- 0.89 [L/kg]/hr, 0.606 +/- 0.535 [L/kg]/hr; p = .390).

CONCLUSIONS

These results suggest that age and gender do not significantly influence DMI clearance or dose-normalized serum concentrations in the pediatric population.

摘要

目的

研究发育及性别对小儿群体中去甲丙咪嗪（DMI）药代动力学的影响。

方法

从173名接受DMI治疗的青少年（90名儿童，83名青少年；29名女性，144名男性）的407份常规采集的、剂量和体重标准化的血清浓度数据中计算DMI药代动力学参数。

结果

整个人群的平均药代动力学参数包括剂量（3.78±1.51mg/kg）、体重和剂量标准化血清浓度（45.41±47.39[μg/L]/[mg/kg]）以及DMI清除率（0.68±1.51[L/kg]/hr）。儿童和青少年在剂量（儿童，青少年）（3.73±1.40mg/kg，3.83±1.68mg/kg）、体重和剂量标准化血清浓度（44.52±39.6[μg/L]/[mg/kg]，46.34±34.89[μg/L]/[mg/kg]；p = 0.62）以及清除率（0.680±0.890[L/kg]/hr，0.695±1.05[L/kg]/hr；p = 0.103）方面未检测到组间差异。男性和女性在剂量（男性，女性）（3.83±1.55mg，3.39±1.84mg）、体重和剂量标准化血清浓度（45.15±37.76[μg/L]/[mg/kg]，47.14±34.96[μg/L]/mg/kg]；p = 0.720）以及清除率（0.699±0.89[L/kg]/hr，0.606±0.535[L/kg]/hr；p = 0.390）方面未检测到组间性别差异。