Jahkola T, Toivonen T, Nordling S, von Smitten K, Virtanen I
Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
Eur J Cancer. 1998 Oct;34(11):1687-92. doi: 10.1016/s0959-8049(98)00215-9.
Tenascin-C (Tn-C) is an extracellular matrix glycoprotein that appears in areas of epithelial-mesenchymal interaction during fetal development and in neoplasia. The immunohistochemical expression of Tn-C and its relationship to histology, nuclear grade, microinvasion, oestrogen (ER) and progesterone receptors (PR), and to cell proliferation measured by Ki-67 expression were studied in 89 intraductal breast carcinomas (DCIS). Periductal Tn-C was noted in 87% and stromal Tn-C in 25% of the tumours. Stromal expression was associated with moderate to strong periductal expression and microinvasion. Periductal expression was associated with comedo-type, nuclear grade, microinvasion, Ki-67 expression, and lack of PR. The distribution of Tn-C was compared in DCIS and in the intraductal component from another series of small axillary node-negative invasive breast carcinomas (n = 44). Tn-C was present in the stroma of pure DCIS in 25% and in the intraductal component of the other series in 82%. Thus, stromal or moderate to strong periductal Tn-C expression in DCIS may relate to early invasion. DCIS with weak periductal or missing Tn-C expression may be a subgroup with benign behaviour.
腱生蛋白-C（Tn-C）是一种细胞外基质糖蛋白，在胎儿发育和肿瘤形成过程中出现在上皮-间质相互作用的区域。在89例乳腺导管内癌（DCIS）中，研究了Tn-C的免疫组化表达及其与组织学、核分级、微浸润、雌激素（ER）和孕激素受体（PR）的关系，以及与通过Ki-67表达测量的细胞增殖的关系。87%的肿瘤中可见导管周围Tn-C，25%的肿瘤中可见间质Tn-C。间质表达与导管周围中度至强表达及微浸润相关。导管周围表达与粉刺型、核分级、微浸润、Ki-67表达及PR缺失相关。比较了DCIS与另一组小的腋窝淋巴结阴性浸润性乳腺癌（n = 44）的导管内成分中Tn-C的分布。25%的纯DCIS间质中有Tn-C，另一组的导管内成分中有82%有Tn-C。因此，DCIS中间质或导管周围中度至强Tn-C表达可能与早期浸润有关。导管周围Tn-C表达弱或缺失的DCIS可能是具有良性行为的一个亚组。
