Barbur J L, Sahraie A, Simmons A, Weiskrantz L, Williams S C
Applied Vision Research Centre, City University, London, UK.
Vision Res. 1998 Nov;38(21):3347-53.
We have investigated the residual processing of chromatic signals in a subject with unilateral damage to the primary visual cortex using psychophysical, pupillometric and functional magnetic resonance imaging (fMRI) methods. Of particular interest was to establish the correlation between the subject's ability to make use of chromatic signals in the blind hemifield to discriminate between different coloured targets, the corresponding residual pupil colour responses and the level and location of cortical activation generated by the same stimuli as revealed by fMRI. The results obtained using the three different experimental approaches are consistent and suggest that retrograde degeneration of thalamic and retinal chromatic processing mechanisms caused by damage to the primary visual cortex in man does not abolish completely the ability to process chromatic signals particularly when large, long-wavelength stimuli are employed.
我们使用心理物理学、瞳孔测量法和功能磁共振成像（fMRI）方法，对一名一侧初级视觉皮层受损的受试者的色觉信号残余处理进行了研究。特别令人感兴趣的是，确定该受试者利用盲侧半视野中的色觉信号来区分不同颜色目标的能力、相应的残余瞳孔颜色反应，以及由相同刺激产生的皮层激活水平和位置（如fMRI所显示）之间的相关性。使用三种不同实验方法获得的结果是一致的，表明人类初级视觉皮层损伤导致的丘脑和视网膜色觉处理机制的逆行性退变，并未完全消除处理色觉信号的能力，尤其是在使用大的长波长刺激时。
