Bente D, Frick K, Lewinsky M, Penning J, Scheuler W
Arzneimittelforschung. 1976;26(6):1120-5.
Ten healthy volunteers received a single oral dose of 100 mg nomifensive, a new antidepressant (tetragtdriusiqyubikube deruvatuve; Hoe 36-984). The drug-induced effects on the EEG were compared with those of placebo. The statistically proved results show that nomifensine causes a distinct shift in vigilance with two different partial processes. After an initially occurring stabilization of the dominant alpha-frequency there appears a polyrhythmic disintegration of the alpha-rhythm with increase of slower and faster frequencies. At the same time a shifting takes place within the beta-range with increasing of 23.5-32.0 Hz-components. Accordingly it is evident that nomifensine results in a typical pharmaco-electroencephalographic profile.
十名健康志愿者单次口服100毫克诺米芬辛，这是一种新型抗抑郁药（四氢喹啉衍生物；Hoe 36 - 984）。将该药物对脑电图的影响与安慰剂的影响进行了比较。经统计学验证的结果表明，诺米芬辛会通过两个不同的部分过程导致警觉性发生明显变化。在最初出现的优势α频率稳定之后，随着较慢和较快频率的增加，α节律出现多节律性解体。同时，在β范围内发生频率变化，23.5 - 32.0赫兹成分增加。因此，很明显诺米芬辛会导致典型的药物脑电图特征。
