Gardner J C, Yazdani F
Department of Radiology, University of Washington, Seattle, USA.
Phys Med Rehabil Clin N Am. 1998 Aug;9(3):569-86, vi.
Although brain magnetic resonance (MR) imaging is increasingly being used as an objective outcome measure in treatment trials for multiple sclerosis (MS), findings correlating conventional MR imaging and disabilities in established MS have been inconsistent. In some studies, measures of MR lesion status, such as numbers of lesions or MS lesion load (volume), have shown limited correlations with clinical scores such as the Kurtzke Expanded disability scale (EDSS). Other studies have shown clear correlations between MR findings and measures of disability in MS. Further development of image processing techniques should help elucidate the relationships between MR findings and disease processes in MS.
尽管脑磁共振成像（MR）越来越多地被用作多发性硬化症（MS）治疗试验中的客观疗效指标，但在已确诊的MS中，传统MR成像与残疾状况之间的相关性研究结果并不一致。在一些研究中，MR病变状态的测量指标，如病变数量或MS病变负荷（体积），与临床评分（如库尔特克扩展残疾量表（EDSS））的相关性有限。其他研究则表明，MR检查结果与MS残疾测量指标之间存在明显的相关性。图像处理技术的进一步发展应有助于阐明MS中MR检查结果与疾病进程之间的关系。
