[戊酰毛花苷（吉托酯）对麻醉猫心血管系统的作用]
[Effects of pentaformylgitoxin (gitoformate) on the cardiovascular system of anesthetized cats].
作者信息
Reuter N, Meyer F
出版信息
Arzneimittelforschung. 1976;26(6):1201-5.
In small and medium doses 3 beta, 14 beta-dihydroxy-16 beta-formyloxy-5 beta-card-20-[22]-enolide-3-tetraformyltridigitoxoside (pentaformylgitoxin; gitoformate) shows a greater positive inotropic and blood pressure increasing potency than do digitoxin and beta-acetyldigoxin. In high doses this influence on contractility is exceeded by digitoxin, that on blood pressure is equalled. None of the substances tested changes heart rate. Arrhythmias with gitoformate are only seen in lethal doses, with digitoxin and beta-acetyldigoxin two dose levels earlier.
在中小剂量时，3β,14β - 二羟基 - 16β - 甲酰氧基 - 5β - 强心甾 - 20 - [22] - 烯醇内酯 - 3 - 四甲酰洋地黄毒苷（五甲酰吉妥辛；吉妥辛甲酸酯）比洋地黄毒苷和β - 乙酰洋地黄毒苷表现出更大的正性肌力作用和升压效力。在高剂量时，洋地黄毒苷对收缩性的影响超过了它，而对血压的影响与之相当。所测试的物质均不改变心率。吉妥辛甲酸酯引起的心律失常仅在致死剂量时出现，而洋地黄毒苷和β - 乙酰洋地黄毒苷在早两个剂量水平时就会出现。
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