Akbar A, Sharma J N, Yusof A P, Gan E K
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains, Penang, Malaysia.
Int J Tissue React. 1998;20(3):95-100.
We studied the effect of indomethacin, a cyclooxygenase inhibitor, on bradykinin-induced responses in the intact and denuded epithelium of the isolated tracheal smooth muscle in guinea pigs. Epithelium removal alone did not alter the responsiveness to bradykinin. Indomethacin (2.8 microM) enhanced the sensitivity to bradykinin of both intact and denuded preparations. This finding suggests that the tracheal epithelial may have no protective effect on the contractile responses induced by bradykinin. This may be due to the presence of high amounts of bradykinin-inactivating enzymes in the tracheal smooth muscle. Indomethacin-medicated potentiation caused by bradykinin in epithelium intact and denuded preparations may be an indication of removal of the bronchodilator prostaglandin biosynthesis. The significance of these findings is discussed.
我们研究了环氧化酶抑制剂吲哚美辛对豚鼠离体气管平滑肌完整和去上皮上皮中缓激肽诱导反应的影响。单独去除上皮不会改变对缓激肽的反应性。吲哚美辛（2.8微摩尔）增强了完整和去上皮制剂对缓激肽的敏感性。这一发现表明，气管上皮可能对缓激肽诱导的收缩反应没有保护作用。这可能是由于气管平滑肌中存在大量缓激肽失活酶。吲哚美辛介导的缓激肽在完整和去上皮制剂中的增强作用可能表明支气管扩张前列腺素生物合成被消除。讨论了这些发现的意义。
