Vital A, Loiseau H, Kantor G, Daucourt V, Chene G, Cohadon F, Rougier A, Rivel J, Vital C
Department of Neuropathology, Hôpital Pellegrin, Bordeaux, France.
Pathol Res Pract. 1998;194(12):831-6. doi: 10.1016/S0344-0338(98)80085-X.
p53 protein expression was evaluated by immunohistochemistry in a homogeneous series of 100 supratentorial grade II astrocytomas with long-term follow-up. The staining was positive in 72 cases. The proportion of p53 positive tumors was slightly higher in younger patients. The tumor regrowths which derived from p53 positive tumors were themselves p53 positive, and this p53 immunopositivity was often stronger than in the initial tumors. All of the 10 gemistocytic astrocytomas included in our series were p53 positive, and age more than histological type appeared decisive in prognosis. p53 protein expression did not quite reach statistical significance as an independent predictive variable in multivariate analysis, whereas survival was related with age, mass effect, surgery and tumor location. Only a tendency to a longer survival was observed on the curves in younger patients with mildly positive tumors.
通过免疫组织化学方法对100例幕上II级星形细胞瘤进行了p53蛋白表达评估，并进行了长期随访。72例染色呈阳性。p53阳性肿瘤在年轻患者中的比例略高。源自p53阳性肿瘤的肿瘤复发本身也是p53阳性，且这种p53免疫阳性通常比初始肿瘤更强。我们系列中的10例肥胖细胞型星形细胞瘤均为p53阳性，年龄比组织学类型在预后方面似乎更具决定性。在多变量分析中，p53蛋白表达作为独立预测变量未达到统计学意义，而生存率与年龄、占位效应、手术及肿瘤位置相关。在肿瘤轻度阳性的年轻患者曲线中仅观察到生存时间延长的趋势。
