Lundqvist G, Flodin U, Axelson O
Department of Health and Environment, Faculty of Health Sciences, Linköping University, Sweden.
Am J Ind Med. 1999 Feb;35(2):132-6. doi: 10.1002/(sici)1097-0274(199902)35:2<132::aid-ajim4>3.0.co;2-i.
Clinical experience of cases of fatty liver disease (FLD) with exposure to organic solvents suggested a possible risk.
Thirty male cases of FLD, ages 20-59 years, with biopsy records at departments of pathology in southeast Sweden were compared to 120 male controls randomly drawn from the study area population. Questionnaire information was obtained about job titles and specific occupational exposures; exposure level categories were then assessed blindly for both cases and controls. Medical records for cases were scrutinized to elucidate possible confounding and/or interacting effects from alcohol, the use of drugs, and other diseases.
Moderately intense and mixed solvent exposure for more than 1 year within the last 15 years prior to diagnosis resulted in an age-adjusted Mantel-Haenszel odds ratio of 4.3 (95% confidence interval (CI), 1.2-15); for intense exposure, the odds ratio was 7.7 (95% CI 1.7-48). Confounding from alcohol, use of drugs, other diseases, and overweight could be ruled out with reasonable confidence.
This study indicates that occupational exposure to organic solvents may play a role in the development of FLD, as indicated earlier in case reports and in one small case-control study.
接触有机溶剂的脂肪肝疾病（FLD）病例的临床经验提示了一种可能的风险。
将瑞典东南部病理学部门有活检记录的30例年龄在20 - 59岁的男性FLD病例与从研究区域人群中随机抽取的120例男性对照进行比较。获取了关于职位和特定职业暴露的问卷信息；然后对病例和对照进行盲法评估暴露水平类别。仔细审查病例的医疗记录以阐明酒精、药物使用和其他疾病可能产生的混杂和/或相互作用影响。
在诊断前的过去15年内，中度强烈和混合溶剂暴露超过1年导致年龄调整后的Mantel-Haenszel比值比为4.3（95%置信区间（CI），1.2 - 15）；对于强烈暴露，比值比为7.7（95%CI 1.7 - 48）。可以有合理把握排除酒精、药物使用、其他疾病和超重造成的混杂影响。
本研究表明，职业性接触有机溶剂可能在FLD的发生中起作用，如之前在病例报告和一项小型病例对照研究中所指出的那样。
