大鼠9L胶质瘤模型中新型硼卟啉化合物的中子俘获治疗
Neutron capture therapy with a new boron-porphyrin compound in the rat 9L glioma model.
作者信息
Shibata Y, Matsumura A, Yamamoto T, Nakagawa K, Yoshii Y, Nose T, Sakata I, Nakajima S, Hayakawa Y, Ono K
机构信息
Dept. of Neurosurgery, University of Tsukuba, Toyo Hakka Co. Ltd., Ibaraki, Japan.
出版信息
J Exp Clin Cancer Res. 1998 Sep;17(3):285-9.
PMID:9894763
Abstract
Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model. Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis, congestion and bleeding were observed in the tumors of the rats which were administered the boron neutron capture therapy.
摘要
用一种新的硼卟啉化合物进行的中子俘获疗法在大鼠脑肿瘤模型中进行了测试。尽管肿瘤中硼的浓度过低，无法产生治疗效果，但在接受硼中子俘获疗法的大鼠肿瘤中观察到了显著的组织病理学变化，如坏死、充血和出血。
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