Tölle T R, Kaufmann T, Siessmeier T, Lautenbacher S, Berthele A, Munz F, Zieglgänsberger W, Willoch F, Schwaiger M, Conrad B, Bartenstein P
Department of Neurology, Technical University, Munich, Germany.
Ann Neurol. 1999 Jan;45(1):40-7. doi: 10.1002/1531-8249(199901)45:1<40::aid-art8>3.0.co;2-l.
Brain imaging with positron emission tomography has identified some of the principal cerebral structures of a central network activated by pain. To discover whether the different cortical and subcortical areas process different components of the multidimensional nature of pain, we performed a regression analysis between noxious heat-related regional blood flow increases and experimental pain parameters reflecting detection of pain, encoding of pain intensity, as well as pain unpleasantness. The results of our activation study indicate that different functions in pain processing can be attributed to different brain regions; ie, the gating function reflected by the pain threshold appeared to be related to anterior cingulate cortex, the frontal inferior cortex, and the thalamus, the coding of pain intensity to the periventricular gray as well as to the posterior cingulate cortex, and the encoding of pain unpleasantness to the posterior sector of the anterior cingulate cortex.
正电子发射断层扫描脑成像已识别出由疼痛激活的中枢网络的一些主要脑结构。为了探究不同的皮质和皮质下区域是否处理疼痛多维度性质的不同组成部分，我们对与有害热相关的局部血流增加和反映疼痛检测、疼痛强度编码以及疼痛不愉快感的实验性疼痛参数进行了回归分析。我们的激活研究结果表明，疼痛处理中的不同功能可归因于不同的脑区；即，疼痛阈值所反映的闸门功能似乎与前扣带回皮质、额下回皮质和丘脑有关，疼痛强度编码与脑室周围灰质以及后扣带回皮质有关，而疼痛不愉快感的编码与前扣带回皮质的后部区域有关。
