Briscoe R J, Gauvin D V
Department of Psychiatry & Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Alcohol. 1999 Jan;17(1):41-5. doi: 10.1016/s0741-8329(98)00032-9.
To assess the interaction of experimentally induced ethanol hangover and cocaine self-administration, rats maintained to self-administer cocaine (0.5 mg/kg/inj) were given either saline or 2 or 4 g/kg ethanol (10% w/v, IP) 15 h prior to cocaine access (dose range tested 0.03-1.0 mg/kg/inj). Cocaine was shown to be dose-dependently self-administered in a significant inverted U-shaped function. EtOH hangover had a significant effect on the dose-dependent effects of cocaine, resulting in a general flattening of the inverted U-shaped function with increasing intensity of hangover. A significant dose-dependent reduction in the number of reinforcer deliveries occurred at the peak of the cocaine dose-response function (0.06 mg/kg/inj) following the 2 and 4 g/kg EtOH pretreatment doses when compared to saline pretreatment. These data suggest that hangover may alter the ability for moderate doses of cocaine to "prime" and maintain stable self-administration behavior.
为评估实验诱导的乙醇宿醉与可卡因自我给药之间的相互作用，对维持自我给药可卡因（0.5毫克/千克/注射）的大鼠，在获取可卡因前15小时给予生理盐水或2克/千克或4克/千克乙醇（10%重量/体积，腹腔注射）（测试的剂量范围为0.03 - 1.0毫克/千克/注射）。可卡因呈现出剂量依赖性的自我给药，呈显著的倒U形函数关系。乙醇宿醉对可卡因的剂量依赖性效应有显著影响，随着宿醉强度增加，倒U形函数总体变平。与生理盐水预处理相比，在2克/千克和4克/千克乙醇预处理剂量后，在可卡因剂量反应函数的峰值（0.06毫克/千克/注射）处，强化物递送次数出现显著的剂量依赖性减少。这些数据表明，宿醉可能会改变中等剂量可卡因“启动”并维持稳定自我给药行为的能力。
