Sack E S, Quiroga E
Thromb Haemost. 1976 Jun 30;35(3):658-68.
A study of platelet aggregation induced by progressive concentrations of collagen was performed in 40 normal persons, equally grouped by sex, immediately before, and 90 min after, the ingestion of 0.500 g aspirin. Simultaneously, serum ASA-esterase activity and plasmatic salicylic acid levels were investigated in the pre- and post-ASA samples respectively. Wide individual variations in platelet responsiveness to collagen were found when the minimal amount of the aggregating agent necessary to provoke significant aggregation was located. The percentage of aggregation and the slope were the most sensible indicators of both the individual variances and the ASA-induced inhibition. Correlation was found in both groups between the minimal amounts of collagen required for initiating aggregation pre- and post-ASA. Also positive correlation was found between the minimal collagen concentration required to initiate aggregation pre-ASA and the aspirin-induced inhibition in the aggregation produced by a higher collagen concentration. Important individual and sexual differences were detected in the serum content of ASA-esterase activity. A negative significant correlation was demonstrated between the ASA-esterase activity and the differences in collagen concentrations necessary to start aggregation pre- and post-aspirin in the men group. Failure to consider individual variances in platelet reactivity may lead to false conclusions about the ASA affectiveness as an antithrombotic agent.
对40名正常受试者进行了一项研究，这些受试者按性别平均分组，在摄入0.500 g阿司匹林之前及之后90分钟，用逐渐增加浓度的胶原蛋白诱导血小板聚集。同时，分别在服用阿司匹林前后的样本中检测血清ASA酯酶活性和血浆水杨酸水平。当找到引发显著聚集所需的最小聚集剂用量时，发现个体对胶原蛋白的血小板反应性存在很大差异。聚集百分比和斜率是个体差异以及阿司匹林诱导抑制的最敏感指标。在两组中均发现服用阿司匹林前后引发聚集所需的最小胶原蛋白量之间存在相关性。同时还发现，服用阿司匹林前引发聚集所需的最小胶原蛋白浓度与较高胶原蛋白浓度产生的聚集过程中阿司匹林诱导的抑制之间呈正相关。在血清ASA酯酶活性的含量方面检测到了重要的个体和性别差异。在男性组中，ASA酯酶活性与服用阿司匹林前后开始聚集所需的胶原蛋白浓度差异之间存在显著负相关。不考虑血小板反应性的个体差异可能会导致关于阿司匹林作为抗血栓药物有效性的错误结论。
