Schmidt A W
Arch Gynakol. 1976 Oct 15;221(3):237-71. doi: 10.1007/BF00667717.
In experiments with animals it was investigated the endurance of the myometrial and the blood flow of the renal cortex during endogenous pressure substances. At the same time it was tested, if treatment with sexual hormones or a pregnancy had the tested principles and changes through pressure substances, and that the changes were significant. The investigations were conducted on three groups of female rabbits. The blood changes in myometrial and in the uterine were measured and continually registered with the special heated thermistor, from the principle of the thermoclearance. The success of the blood pressure was intraarterial measured with an electric mechanism. Precisely the same doses (in relativity of the animals weight) of pressure substances were applied with an infusions pump intravenously. And pressure substances Angiotensin II, Norepinephrine and Epinephrine, and their actions on the blood pressure and blood flow through the myometrium and through the renal cortex were examined. Altogether 131 values were registered. The results of the study that were statistically secure were as follows: a) The uterine blood flow pro tissue volume unit stays constant also by pregnancy or pseudopregnancy. b) The blood flow of the kidney is perhaps twice as high as the myometrial. c) The myometrial blood flow is with the arterial systolic blood pressure tightly correlated. Blood pressure increases through Angiotensin-infusion and also recovery of the uterine blood flow. d) An autoregulation of the uterine blood flow is not observed. e) The decrease of the renal blood flow after the giving of pressure substances was not modified through pregnancy. f) In quality the behaviour of the organ blood flow is the same after applied infusion of the pressure substances. Quantity differences exist however between Angiotensin II, Norepinephrine and Epinephrine. The method of measuring the blood flow through the uterus and in the kidney was placed in one view there. The finding of another examination groups for the problem of the organ blood flow in pregnancy was under critical consideration the methods combined and in connection with the proper examinations discussed. Till now in the theory over the cause of EPH-syndrom the predominate recently compiled comprehensive summary was; the proper body pressure substances--especially from the renin Angiotensin system--after chronical invoices it was decides diminished uterus blood flow appeared. After the earlier results were not all secure. The proper examination speech was therefore, that regarding the kidney function relevant alterations, also unter the conditions of pregnancy, are to be observed. The pressure dependant regulation of myometrial blood flow without proving autoregulation required however another test of the predominante gestose theory.
在动物实验中，研究了内源性升压物质作用下子宫肌层的耐力和肾皮质的血流量。同时，测试了性激素治疗或妊娠是否会通过升压物质引发所测试的原理及变化，且这些变化具有显著性。研究在三组雌性兔子身上进行。利用热清除原理，通过特殊的加热热敏电阻测量并持续记录子宫肌层和子宫内的血液变化。采用电动装置经动脉测量血压。使用输液泵静脉注射精确相同剂量（相对于动物体重）的升压物质。研究了升压物质血管紧张素II、去甲肾上腺素和肾上腺素及其对血压以及通过子宫肌层和肾皮质的血流量的作用。总共记录了131个值。该研究的统计学可靠结果如下：a）每单位组织体积的子宫血流量在妊娠或假妊娠时也保持恒定。b）肾脏的血流量可能是子宫肌层血流量的两倍。c）子宫肌层血流量与动脉收缩压密切相关。通过输注血管紧张素使血压升高，子宫血流量也随之恢复。d）未观察到子宫血流量的自身调节。e）给予升压物质后肾血流量的减少并未因妊娠而改变。f）在输注升压物质后，器官血流量的性质相同。然而，血管紧张素II、去甲肾上腺素和肾上腺素之间存在量的差异。展示了测量子宫和肾脏血流量的方法。对于妊娠中器官血流量问题的另一组检查结果，正在批判性地考虑所结合的方法，并结合适当的检查进行讨论。到目前为止，在关于妊娠高血压综合征病因的理论中，最近汇编的主要综合总结是：在长期发病后，体内适当的升压物质——尤其是来自肾素 - 血管紧张素系统的物质——决定了子宫血流量减少。但早期结果并非都可靠。因此，恰当的检查表明，在妊娠情况下，也应观察与肾功能相关的改变。然而，子宫肌层血流量的压力依赖性调节在未证明自身调节的情况下，需要对占主导地位的妊娠理论进行另一项测试。
