Tanifuji Y, Eger E I
Br J Anaesth. 1976 Oct;48(10):947-52. doi: 10.1093/bja/48.10.947.
In the dog a reduction of mean arterial pressure to 40-50 mm Hg decreased MAC by 20+/--EM 4% in the 1st hour. No further change resulted during the ensuing 3 h of hypotension (40-50 mm Hg). Arterial and cerebrospinal fluid lactate and pyruvate concentrations were not affected by hypotension, nor did cerebrospinal fluid pH decrease. In a separate group of dogs, we reduced arterial pressure to 40-50, 30-40 and 20-30 mm Hg successively. MAC decreased concomitantly, being 58+/-11% of control value at the lowest pressure. MAC increased following the restoration of normal pressure, but hysteresis was evident. In a third group of dogs, arterial pressure was reduced rapidly to 10-30 mm Hg. MAC decreased to 29+/-5% of control. This decrease was significantly greater than that associated with the three-stage reduction.
在犬类中，平均动脉压降至40 - 50毫米汞柱时，在第1小时内最低肺泡有效浓度（MAC）降低了20±4%。在随后3小时的低血压期（40 - 50毫米汞柱），未出现进一步变化。动脉血和脑脊液中的乳酸及丙酮酸浓度不受低血压影响，脑脊液pH值也未降低。在另一组犬类中，我们先后将动脉压降至40 - 50、30 - 40和20 - 30毫米汞柱。MAC随之降低，在最低压力时为对照值的58±11%。恢复正常压力后MAC升高，但滞后现象明显。在第三组犬类中，动脉压迅速降至10 - 30毫米汞柱。MAC降至对照值的29±5%。这种降低显著大于与三阶段降压相关的降低幅度。
