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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Fletcher L, Rider C C, Taylor C B

Biochim Biophys Acta. 1976 Nov 8;452(1):245-52. doi: 10.1016/0005-2744(76)90077-2.

The chromatography of rat brain enolase (2-phospho-D-glycerate hydrolyase, EC 4.2.1.11) reveals three distinet components. One of these appears to be isoenzyme 1 (alpha alpha) but isoenzymes 2 (alpha beta) and 3 (beta beta) are absent. 2. The most acidic form of brain enolase was partially purified and an antiserum raised against it in the chicken. 3. a combination of chromatographic and immunological studies showed that a third type of subunit (gamma) is present in the brain giving rise to two further isoenzymes (alpha gamma and gamma gamma). 4. Developmental studies on the brain enzyme show an increase in total enolase activity from foetal life to maturity and a concurrent rise in the proportion of brain specific dimers. 5. It is therefore concluded that there are three genetic loci alpha, beta and gamma, coding for the enolase isoenzymes of rat tissues.

大鼠脑烯醇化酶（2-磷酸-D-甘油酸水解酶，EC 4.2.1.11）的色谱分析显示有三个不同的组分。其中一个似乎是同工酶1（αα），但不存在同工酶2（αβ）和同工酶3（ββ）。2. 脑烯醇化酶的最酸性形式被部分纯化，并在鸡体内产生了针对它的抗血清。3. 色谱和免疫学研究相结合表明，脑中存在第三种亚基（γ），产生另外两种同工酶（αγ和γγ）。4. 对脑酶的发育研究表明，从胎儿期到成熟期，总烯醇化酶活性增加，同时脑特异性二聚体的比例也随之上升。5. 因此得出结论，存在三个基因位点α、β和γ，它们编码大鼠组织的烯醇化酶同工酶。

Fletcher L, Rider C C, Taylor C B

Biochim Biophys Acta. 1976 Nov 8;452(1):245-52. doi: 10.1016/0005-2744(76)90077-2.

The chromatography of rat brain enolase (2-phospho-D-glycerate hydrolyase, EC 4.2.1.11) reveals three distinet components. One of these appears to be isoenzyme 1 (alpha alpha) but isoenzymes 2 (alpha beta) and 3 (beta beta) are absent. 2. The most acidic form of brain enolase was partially purified and an antiserum raised against it in the chicken. 3. a combination of chromatographic and immunological studies showed that a third type of subunit (gamma) is present in the brain giving rise to two further isoenzymes (alpha gamma and gamma gamma). 4. Developmental studies on the brain enzyme show an increase in total enolase activity from foetal life to maturity and a concurrent rise in the proportion of brain specific dimers. 5. It is therefore concluded that there are three genetic loci alpha, beta and gamma, coding for the enolase isoenzymes of rat tissues.

大鼠脑烯醇化酶（2-磷酸-D-甘油酸水解酶，EC 4.2.1.11）的色谱分析显示有三个不同的组分。其中一个似乎是同工酶1（αα），但不存在同工酶2（αβ）和同工酶3（ββ）。2. 脑烯醇化酶的最酸性形式被部分纯化，并在鸡体内产生了针对它的抗血清。3. 色谱和免疫学研究相结合表明，脑中存在第三种亚基（γ），产生另外两种同工酶（αγ和γγ）。4. 对脑酶的发育研究表明，从胎儿期到成熟期，总烯醇化酶活性增加，同时脑特异性二聚体的比例也随之上升。5. 因此得出结论，存在三个基因位点α、β和γ，它们编码大鼠组织的烯醇化酶同工酶。